Recombinant Mouse KIRREL1/NEPH1 Protein (His Tag)

Recombinant Mouse KIRREL1/NEPH1 Protein (His Tag)

• Background: Kin of irregular chiasm-like protein 1(Kirrel1), also known as Nephrin-like protein 1(Neph1), belongs to the immunoglobulin superfamily. Kirrel1 plays a significant role in the normal development and function of the glomerular permeability. It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. The knockout of this gene could result in perinatal lethality accompanied by proteinuria, and effacement of glomerular podocytes. Kirrel1 is abundantly expressed in kidney and specifically expressed in podocytes of kidney glomeruli. Its’ subunit interacts with TJP1/ZO-1 and with NPHS2/podocin (via the C-terminus) and interacts with NPHS1/nephrin (via the Ig-like domains). This interaction is dependent on KIRREL glycosylation. Kirrel1 also interacts when tyrosine-phosphorylated with GRB2.
• Abbreviation: KIRREL1;NEPH1
• Synonyms: Kin of IRRE-like protein 1, Kin of irregular chiasm-like protein 1, Kirrel1, Neph1, Nephrin-like protein 1
• CAS Number: 9000-83-3
• UniProt: Q80W68
• Accession Number: Q80W68
• Host: HEK293 Cells
• Origin Species: Mouse
• Tag: C-His
• Sequence: Leu48-Leu525
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 70-85 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.