Recombinant Mouse CD16/FCGR3 Protein (His Tag)

Recombinant Mouse CD16/FCGR3 Protein (His Tag)

• Background: Low affinity immunoglobulin gamma Fc region receptor III (Fc gamma RIII/CD16) is a member of the Ig superfamily. Based on close relationships in their extracellular domains, the Fc gamma Rs have been divided into three classes composing of Fc gamma RI (CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. Mouse CD16 is a type I transmembrane protein having two extracellular Ig-like domains consisting of immunoglobulin domain, repeat, signa and transmembrane, transmembrane helix. It is expressed on a variety of myeloid and lymphoid cells and associates with Fc R gamma to deliver an activating signal upon ligand binding. Fcgr3 is IgG binding and activation or inhibition of immune responses such as antibody-dependent cellular cytotoxicity, phagocytosis, cell surface receptor signaling pathway and positive regulation of type I/IIa/III hypersensitivity.
• Abbreviation: CD16;FCGR3
• Synonyms: CD-antigen 16, CD16, Fc gamma Receptor III, FcRIII, Fcgr3, IgG Fc receptor III, Low affinity immunoglobulin gamma Fc region receptor III
• CAS Number: 9000-83-3
• UniProt: P08508
• Accession Number: P08508
• Host: HEK293 Cells
• Origin Species: Mouse
• Tag: C-His
• Sequence: Ala31-Thr215
• Applications: BLI
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Loaded Recombinant Mouse IgG2a Fc on AMC Biosensor, can bind Recombinant Mouse CD16 with an affinity constant of 0.16 uM as determined in BLI assay.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 35-40 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.