Recombinant Mouse TSLP Receptor/CRLF2 Protein (Fc Tag)

Recombinant Mouse TSLP Receptor/CRLF2 Protein (Fc Tag)

• Background: The cytokine thymic stromal lymphopoietin receptor (TSLPR) is consisting of a common γ receptor–like chain (TSLPR-γ) and a common interleukin 7 (IL-7) Rα chain that belongs to the type 1 cytokine receptor family. Transfection of TSLPR cDNA result in only low affinity binding, while cotransfection of the IL-7Rα chain cDNA shows high affinity binding. TSLP and TSLPR play a critical role in the initiation of allergic diseases in mice. The TSLP R cDNA encodes a transmembrane receptor containing 370 amino acids (aa) with two potential N-linked glycosylation sites and a cytoplasmic domain of 104 aa including a single tyrosine residue. TSLPR can mediate signaling of the signal transducer and activator of transcription 5 (Stat5) by TSLP. TSLP R is broadly expressed in the immune and hematopoietic cells, particularly in hematopoietic progenitors and myeloid cells.
• Abbreviation: TSLP Receptor;CRLF2
• Synonyms: CRL2, CRL2 cytokine receptor, CRLF2, IL-XR, ILXR, P2RY8/CRLF2 fusion, TSLP receptor, TSLPR, Thymic stromal lymphopoietin protein receptor, Thymic stromal-derived lymphopoietin receptor, cytokine receptor-like factor 2
• CAS Number: 9000-83-3
• UniProt: Q8CII9
• Accession Number: AAH23788.1
• Host: HEK293 Cells
• Origin Species: Mouse
• Tag: C-Fc
• Sequence: Ala20-Leu233
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 62-88 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.