Recombinant Mouse TSLP Receptor/CRLF2 Protein (Fc Tag)

• Background:

  The cytokine thymic stromal lymphopoietin receptor (TSLPR) is consisting of a common γ receptor–like chain (TSLPR-γ) and a common interleukin 7 (IL-7) Rα chain that belongs to the type 1 cytokine receptor family. Transfection of TSLPR cDNA result in only low affinity binding, while cotransfection of the IL-7Rα chain cDNA shows high affinity binding. TSLP and TSLPR play a critical role in the initiation of allergic diseases in mice. The TSLP R cDNA encodes a transmembrane receptor containing 370 amino acids (aa) with two potential N-linked glycosylation sites and a cytoplasmic domain of 104 aa including a single tyrosine residue. TSLPR can mediate signaling of the signal transducer and activator of transcription 5 (Stat5) by TSLP. TSLP R is broadly expressed in the immune and hematopoietic cells, particularly in hematopoietic progenitors and myeloid cells.

• Abbreviation:

  TSLP Receptor; CRLF2

• Synonyms:

  CRL2; CRL2 cytokine receptor; CRLF2; IL-XR; ILXR; P2RY8/CRLF2 fusion; TSLP receptor; TSLPR; Thymic stromal lymphopoietin protein receptor; Thymic stromal-derived lymphopoietin receptor; cytokine receptor-like factor 2

• UniProt:

  Q8CII9

• Accession Number:

  AAH23788.1

• Expression System:

  HEK293 Cells

• Tag:

  C-Fc

• Sequence:

  Ala20-Leu233

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  49.8 kDa

• Observed Molecular Weight:

  62-88 kDa

• Species:

  Mouse