Recombinant Mouse SIRPA/CD172a Protein (MIgG2a Tag)

Recombinant Mouse SIRPA/CD172a Protein (MIgG2a Tag)

• Background: SIRPα is a type I transmembrane glycoprotein.It contains two Ig-like C1-type domains and one Ig-like V-type domain. Mouse SIRP alpha ECD shares 61%, 75%, 62%, 61%, and 59% aa sequence identity with human, rat, equine, bovine, and porcine SIRP alpha, respectively.SIRPα can express in various tissues, mainly on brain and myeloid cells, including macrophages, neutrophils, dendritic and Langerhans cells. It also can detect in neurons, smooth muscle and endothelial cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPα acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα shows adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. SIRPα engagement generally produces a negative regulatory signal; it may mediate negative regulation of phagocytosis, mast cell activation and dendritic cell activation.
• Abbreviation: SIRPA;CD172a
• Synonyms: CD172 Antigen-Like Family Member A, CD172a, MFR, SHPS1, SIRP, SIRPA, Signal-Regulatory Protein Alpha-1, Tyrosine-Protein Phosphatase Non-Receptor Type Substrate 1
• CAS Number: 9000-83-3
• UniProt: Q6P6I8
• Accession Number: Q6P6I8
• Host: HEK293 Cells
• Origin Species: Mouse
• Tag: C-mIgG2a Fc
• Sequence: Lys32-Asn372
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 90-120 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.