Recombinant Mouse Interleukin-4/IL-4 Protein (His Tag)

Recombinant Mouse Interleukin-4/IL-4 Protein (His Tag)

• Background: Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 is produced by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergic response.
• Abbreviation: Interleukin-4;IL-4
• Synonyms: Interleukin, B-cell growth factor, B-cell stimulatory factor, Lymphocyte stimulatory factor, BCGF1, BSF-1, B-cell growth factor 1, B-cell IgG differentiation factor, B-cell stimulatory factor 1, BCGF-1, BSF1, IGG1 induction factor, Interleukin-4, Lymphocyte stimulatory factor 1, Il-4, Il4
• CAS Number: 9000-83-3
• UniProt: P07750
• Accession Number: P07750
• Host: HEK293 Cells
• Origin Species: Mouse
• Tag: C-His
• Sequence: His21-Ser140
• Applications: Cell culture
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Measured in a cell proliferation assay using M-NFS-60 mouse lymphoblast cells. The ED₅₀ for this effect is 0.035 ng/ml.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 15-19 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.