Recombinant Mouse CTLA4 Protein (Fc Tag)

Recombinant Mouse CTLA4 Protein (Fc Tag)

• Background: Mouse Cytotoxic Tlymphocyte 4(CTLA-4,CD152), is a type I transmembrane T cell inhibitory molecule. Within the ECD, Mouse CTLA-4 shares 68% aa sequence identity with human. CTLA4 is similar to the T cell costimulatory protein CD28 since both of the molecules bind to CD80 and CD86 on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found inregulatory T cells and may play an important role in their functions. T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA4. Genetic variations of CTLA4 have been associated with susceptibility to systemic lupus erythematosus(SLE), Gravesdisease(GRD), Celiac disease type3(CELIAC3) and Hepatitis B virus infection(HBVinfection).
• Abbreviation: CTLA4
• Synonyms: CD152, CTLA-4, Ctla4 , Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4
• CAS Number: 9000-83-3
• UniProt: P09793
• Accession Number: P09793
• Host: HEK293 Cells
• Origin Species: Mouse
• Tag: C-Fc
• Sequence: Ala37-Asp161
• Applications: BLI
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Loaded Human B7-2-His on HIS1K Biosensor, can bind Mouse CTLA-4-Fc with an affinity constant of 5.65 nM as determined in BLI assay.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 50-60 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.