Recombinant Mouse CD86/B7-2 Protein (His Tag)
CAT:
763-PKSM040944
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Mouse CD86/B7-2 Protein (His Tag)
- Background: CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co-stimulatory receptors CD28 and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) expressed on T cells, and thus induces the signal pathways which regulate T cell activation and tolerance, cytokine production, and the generation of CTL. It is indicated that contacts between B and T helper cells mediated by CD86 encourage signals for the proliferation and IgG secretion of normal B cells and B cell lymphomas. Recent study has revealed that CD86 also promotes the generation of a mature APC repertoire and promotes APC function and survival. CD86 has an important role in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, and thus is regarded as a promising candidate for immune therapy.
- Synonyms: Activation B7-2 antigen, B7, B7-2, B7.2, B70, CD86, CLS1, Cd28l2, ETC-1, Early T-cell costimulatory molecule 1, Ly-58, Ly58, MB7, MB7-2, T-lymphocyte activation antigen CD86, TS/A-2
- CAS Number: 9000-83-3
- UniProt: P42082
- Accession Number: NP_062261.3
- Host: HEK293 Cells
- Origin Species: Mouse
- Tag: C-His
- Sequence: Met 1-Glu 245
- Applications: ELISA
- Purity: > 92 % as determined by reducing SDS-PAGE.
- Bioactivity: Immobilized mouse CD86 at 20 μg/ml (100 μl/well) can bind mouse CD28 with a linear ranger of 6. 4-800 ng/ml.
- Reconstitution: Please refer to the printed manual for detailed information.
- Molecular Weight: 40-55 kDa
- Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
- Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.