Recombinant Human P-selectin/CD62P (C-Fc)

Recombinant Human P-selectin/CD62P (C-Fc)

• Background: P-selectin/CD62P is a single-pass type I membrane protein which is a member of the Selectin family. It consists 768 amino acid (aa). P-selectin is a cell surface glycoprotein expressed by activated platelets and endothelial cells. It induced expression in lung, liver, kidney and heart after endotoxin treatment. Ca2+-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. It mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. it also mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1. P-selectin interacts with SNX17, PSGL1/SEPL, PODXL2, mediates neutrophil adhesion and leukocyte rolling. This interaction requires the sialyl-Lewis X epitope of PSGL1 and PODXL2, and specific tyrosine sulfation on PSGL1.
• Abbreviation: P-selectin;CD62P
• Synonyms: CD62 antigen-like family member P, GMP-140, Granule membrane protein 140, LECAM3, Leukocyte-endothelial cell adhesion molecule 3, P-selectin, PADGEM
• CAS Number: 9000-83-3
• UniProt: P16109
• Accession Number: P16109
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-Fc
• Sequence: Trp42-Ala771
• Field of Research: Cardiovascular;immunology;Stem cells
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 130-160 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.