Recombinant Human Dickkopf-Related Protein 1/DKK-1 (C-Fc)

Recombinant Human Dickkopf-Related Protein 1/DKK-1 (C-Fc)

• Background: Dickkopf-related protein 1(DKK-1), is a member of the dickkopf family. DKK1 secreted proteins with two cysteine-rich domains separated by a linker region. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
• Abbreviation: DKK1;Dkk-1
• Synonyms: Dickkopf-1, Dickkopf-related protein 1, Dkk-1
• CAS Number: 9000-83-3
• UniProt: O94907
• Accession Number: O94907
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-Fc
• Sequence: Thr32-His266
• Field of Research: Cardiovascular;Developmental Biology;immunology;Stem cells
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 60-80 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.