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Recombinant Human LEPR (C-Fc)

CAT:
763-PKSH034018-01
Size:
50 µg
Price:
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For price, please contact [email protected]
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
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Recombinant Human LEPR (C-Fc)

  • Background: The Leptin receptor is a member of the Class I cytokine receptor family. It mediates the activities of Leptin, a multi-functional hormone produced primarily by adipose tissues that plays roles in food intake, energy metabolism, angiogenesis, reproduction, hematopoiesis, bone metabolism, and immune function. The human Leptin R gene encodes 1165 amino acids (aa) including a signal peptide, an extracellular region with cytokine receptor homology (CRH), multiple fibronectin type III domains and a WSXWS motif, a transmembrane domain, and a cytoplasmic domain that supports JAK/STAT signaling. Soluble Leptin R is the primary Leptin-binding protein in blood, where it maintains a pool of available bioactive Leptin, delays Leptin clearance from circulation, and down-regulates blood-brain transmission of Leptin. In humans, soluble Leptin R levels are inversely proportional to adiposity and are elevated in females versus males. Soluble Leptin R is also found up-regulated in patients with chronic heart failure, end-stage renal disease, and anorexia.It is expressed by tumor-initiating stem cells, and is proposed as a link between cancer and obesity.
  • Abbreviation: LEPR
  • Synonyms: CD295, DB, HuB219, LEP-R, LEPR, Leptin receptor, OB receptor, OB-R, OBR
  • CAS Number: 9000-83-3
  • UniProt: P48357
  • Accession Number: P48357
  • Host: HEK293 Cells
  • Origin Species: Human
  • Tag: C-Fc
  • Sequence: Phe22-Asp839
  • Field of Research: Signal Transduction;Cardiovascular;Cancer;metabolism;
  • Purity: > 90 % as determined by reducing SDS-PAGE.
  • Bioactivity: Not validated for activity
  • Reconstitution: Please refer to the printed manual for detailed information.
  • Molecular Weight: 150-180 kDa
  • Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
  • Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

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