Recombinant Human DC-SIGN/CD209 (N-Fc)

Recombinant Human DC-SIGN/CD209 (N-Fc)

• Background: CD209 is also known as CLEC4L, DC-SIGN and CD209 antigen, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. The DC-SIGN/CD209 lectin domain binds mannose oligosaccharides on pathogens including HIV as well as self glycoproteins including ICAMs (2, 4). DC-SIGN/CD209 binds to butyrophilin 2A1 and this interaction can be blocked by HIV pp120. DC-SIGN/CD209 is expressed on dendritic cells (DC) and inflammatory macrophages and contributes to antigen presentation. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors.
• Abbreviation: DC-SIGN;CD209
• Synonyms: CD209, CD209 Antigen, CD209 molecule, CDSIGNHIV gpl20-binding protein, CLEC4L, DC-SIGN, DC-SIGN1, DCSIGN
• CAS Number: 9000-83-3
• UniProt: Q9NNX6
• Accession Number: Q9NNX6
• Host: HEK293 Cells
• Origin Species: Human
• Tag: N-Fc
• Sequence: Gln59-Ala404
• Field of Research: Signal Transduction;Microbiology;immunology;
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 75 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.