Recombinant Human Angiopoietin-1/ANG1 (N-Fc)

• Background:

  Angiopoietin-1 (Ang-1) is a secreted glycoprotein that plays a critical role in the development and maintenance of the vascular system. The angiopoietin (ANGPT) -TIE2/TEK signaling pathway is essential for blood and lymphatic vascular homeostasis. ANGPT1 is a potent TIE2 activator, whereas ANGPT2 functions as a context-dependent agonist/antagonist. Angiopoietin-1 can protect against pulmonary arterial hypertension, reduce the extent of fibrosis and remodeling in infarcted diabetic myocardium, and enhance tumor progression and metastasis.

• Abbreviation:

  Angiopoietin-1; ANG1

• Synonyms:

  AGP1; AGPT; ANG-1; ANGPT1; Ang1; Angiopoietin-1; angiopoietin 1

• UniProt:

  Q15389

• Accession Number:

  Q15389

• Expression System:

  HEK293 Cells

• Tag:

  N-Fc

• Sequence:

  Asp256-Phe498

• Field of Research:

  Cardiovascular; Cancer; metabolism

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  53.9 kDa

• Observed Molecular Weight:

  55-65 kDa

• Species:

  Human