Recombinant Human TMED1 (C-Fc)

Recombinant Human TMED1 (C-Fc)

• Background: TMED1 (Transmembrane Emp24 domain-containing protein 1) is a member of the TMED family of proteins (gene name TMED1). The TMED family of proteins are localized to membranes of the early secretory pathway, including the endoplasmic reticulum and Golgi, and function in vesicular protein trafficking. TMED1 is a 59 kDa monomer and has been reported to exist as homodimer. It contains 1 GOLD domain and is widely expressed. TMED1 is important in regulating innate immune signaling through its interaction with ST2L. Specifically, the GOLD domain in TMED1 interacts with the TIR domain of ST2L, a receptor for IL 33. This interaction promotes ST2L association with IL-33, allowing downstream signaling cascade activating MAP kinases, p38, and JNK. Studies have shown knockdown of TMED-1 in HUVECs impairs the IL-33 induced response resulting in reduction of IL-6 and IL-8 productions.
• Abbreviation: TMED1
• Synonyms: IL-1RL1LG, IL1RL1-Binding Protein, IL1RL1LG, IL1RL1LGIL1RL1-binding protein, Il1rl1l, ST2L, T1/ST2 receptor binding protein, TMED1, Tp24
• CAS Number: 9000-83-3
• UniProt: Q13445
• Accession Number: Q13445
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-Fc
• Sequence: Ala24-Asn194
• Field of Research: Cell biology
• Purity: > 90 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 55-65 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.