Recombinant Human Integrin Beta-1/ITGB1 (C-6His)

• Background:

  Integrin β-1 (ITGB1) belongs to the integrin β chain family. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. ITGB1 is an integrin unit associated with very late antigen receptors, which contains one VWFA domain. It is known to conjoin with α-3 subunit to create α3β1 complex that reacts to such molecules as netrin-1 and reelin.

• Abbreviation:

  Integrin Beta-1, ITGB1

• Synonyms:

  CD29; FNRB; Fibronectin Receptor Subunit Beta; ITGB1; Integrin Beta-1; MDF2; MSK12; VLA-4 Subunit Beta

• UniProt:

  P05556

• Accession Number:

  P05556

• Expression System:

  HEK293 Cells

• Tag:

  C-His

• Sequence:

  Gln21-Asp728

• Field of Research:

  Signal Transduction; Microbiology; Neuroscience; Cancer; Developmental Biology; metabolism; Stem cells

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 90 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  79.4 kDa

• Observed Molecular Weight:

  100 - 130 kDa

• Formulation:

  Lyophilized from a 0.2 µm filtered solution of PBS, pH 7.4.
  Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
  Please refer to the specific buffer information in the printed manual.

• Species:

  Human