Recombinant Human CD80/B7-1 Protein (mFc Tag)

Recombinant Human CD80/B7-1 Protein (mFc Tag)

• Background: Cluster of Differentiation 80, also called B7-1, is a member of cell surface immunoglobulin superfamily which plays key, yet distinct roles in the activation of T cells. It is the ligand for two different proteins on the T cell surface: CD28 and CTLA-4. Studies have shown that CTLA-4 binds mostly to CD80. The structure presents two extracellular domains: a membrane distal variable-like domain (IgV) and a membrane proximal Ig constant-like domain (IgC) along with an intracellular domain. Both IgV and IgC consist of anti-parallel beta sandwiches joined by a short linker region. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells, macrophages and dendritic cells.
• Abbreviation: CD80;B7-1
• Synonyms: Activation B7-1 antigen, B7, B7-1, B7.1, BB1, CD28LG, CD28LG1, CD28LGB7-1 antigen, CD80, LAB7, T-lymphocyte activation antigen CD80
• CAS Number: 9000-83-3
• UniProt: P33681
• Accession Number: P33681
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-mFc
• Sequence: Val35-Leu242
• Field of Research: immunology;Stem cells
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 70-95 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.