Recombinant Human Interleukin-15/IL-15 Protein
CAT:
763-PKSH033630-02
Size:
20 µg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Human Interleukin-15/IL-15 Protein
- Background: Human Interleukin 15 (IL-15) is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL15 receptor (IL-15RA) with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs. Mature Human IL-15 shares 70% amino acid sequence identity with Mouse and Rat IL-15.
- Abbreviation: Interleukin-15;IL-15
- Synonyms: IL-15, Interleukin 15, Interleukin-15, IL15
- CAS Number: 9000-83-3
- UniProt: P40933
- Accession Number: P40933
- Host: E. coli
- Origin Species: Human
- Tag: N-His
- Sequence: Asn49-Ser162
- Applications: Cell culture
- Field of Research: Cancer;immunology;metabolism
- Purity: > 95 % as determined by reducing SDS-PAGE.
- Bioactivity: Measure by its ability to induce proliferation in CTLL-2 cells. The ED50 for this effect is < 3 ng/mL. The specific activity of recombinant human IL-15 is > 2 x 106 IU/mg.
- Reconstitution: Please refer to the printed manual for detailed information.
- Molecular Weight: 13 kDa
- Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
- Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.