Recombinant Human Interleukin-17D/IL-17D Protein

Recombinant Human Interleukin-17D/IL-17D Protein

• Background: The Interleukin-17 family proteins, comprising six members (IL-17, IL-17B through IL-17F),are secreted, structurally related proteins that share a conserved cysteine-knot fold near the C-terminus, but have considerable sequence divergence at the N-terminus. IL-17 family proteins are proinflammatory cytokines that induce local cytokine production and are involved in the regulation of immune functions. Among IL-17 family members, IL-17D is most closely related to IL-17B, sharing 27% aa sequence homology. IL-17D is expressed preferentially in skeletal muscle, heart, adipose tissue, lung, pancreas, and nervous system. Like other IL-17 family members, IL-17D modulates immune responses indirectly by stimulating the production of myeloid growth factors and chemokines including IL-6, IL-8, and GM-CSF. IL-17D has also been shown to suppress the proliferation of myeloid progenitors in colony formation assays.
• Abbreviation: Interleukin-17D;IL-17D
• Synonyms: UNQ, IL 27, IL-27, IL 17D, IL 22, IL-17D, IL27, Interleukin 17D, Interleukin 27, Interleukin-17D, Interleukin-27, IL17D, UNQ3096, PRO21175
• CAS Number: 9000-83-3
• UniProt: Q8TAD2
• Accession Number: Q8TAD2
• Host: E. coli
• Origin Species: Human
• Tag: N-His
• Sequence: Ala18-Pro202
• Field of Research: Cancer;immunology
• Purity: > 98 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 17-34 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.