Recombinant Human FLT-3/FLK-2 Protein (Fc Tag)

Recombinant Human FLT-3/FLK-2 Protein (Fc Tag)

• Background: The Flt-3 (fms-like tyrosine kinase) receptor, also named Flk-2and Stk-1is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the receptor for SCF and FMS, the receptor for M-CSF. The extracellular region of these receptors contains five immunoglobulin-like domains and the intracellular region contains a split kinase domain. Human Flt-3 cDNA encodes a 993 amino acid (aa) residue type I membrane protein with a 26 aa residue signal peptide, a 515 aa extracellular domain with 10 potential N-linked glycosylation sites, a 21 aa residue transmembrane domain and a 431 aa residue cytoplasmic domain. Flt-3 expression has been detected in various tissues, including placenta, gonads, and tissues of nervous and hematopoietic origin. Among hematopoietic cells, the expression of Flt-3 was found to be restricted to the highly enriched stem/progenitor cell populations. The ligand for Flt-3 (FL) has been identified to be a transmembrane protein with structural homology to M-CSF and SCF. Recombinant soluble Flt-3/Fc chimeric protein has been shown to bind FL with high affinity and is a potent FL antagonist.
• Abbreviation: FLT-3;FLK-2
• Synonyms: CD135, FL Cytokine Receptor, FLK-2, FLK2, FLT-3, FLT3, Fetal Liver Kinase-2, Fms-Like Tyrosine Kinase 3, Receptor-Type Tyrosine-Protein Kinase FLT3, STK-1, STK1, Stem Cell Tyrosine Kinase 1
• CAS Number: 9000-83-3
• UniProt: P36888
• Accession Number: AAI26351.1
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-Fc
• Sequence: Asn27-Asn541
• Field of Research: Signal Transduction;immunology;
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Not Applicable
• Molecular Weight: 120 kDa
• Shipping Conditions: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
• Storage Conditions: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.