Recombinant Human UBE2M/UBC12 Protein
CAT:
763-PKSH033478-02
Size:
10 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Human UBE2M/UBC12 Protein
- Background: UBE2M is a member of the E2 ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes; or E1s; ubiquitin-conjugating enzymes; or E2s; and ubiquitin-protein ligases; or E3s. This protein is linked with a ubiquitin-like protein; NEDD8; which can be conjugated to cellular proteins; such as Cdc53/culin. UBE2M accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1; but not RBX2; suggests that the RBX1-UBE2M complex neddylates specific target proteins; such as CUL1; CUL2; CUL3 and CUL4. It involved in cell proliferation and is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.
- Abbreviation: UBE2M;UBC12
- Synonyms: NEDD8 carrier protein, NEDD8 protein ligase, NEDD8-conjugating enzyme Ubc12, UBC12, UBE2M, Ubiquitin-conjugating enzyme E2 M
- CAS Number: 9000-83-3
- UniProt: P61081
- Accession Number: P61081
- Host: E. coli
- Origin Species: Human
- Tag: None
- Sequence: Met1-Lys183
- Field of Research: Cell biology;epigenetics and nuclear signal
- Purity: > 95 % as determined by reducing SDS-PAGE.
- Bioactivity: Not validated for activity
- Reconstitution: Not Applicable
- Molecular Weight: 25 kDa
- Shipping Conditions: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
- Storage Conditions: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.