Recombinant Human Interleukin-4/IL-4 Protein

Recombinant Human Interleukin-4/IL-4 Protein

• Background: Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates diverse T and B cell responses including cell proliferation; survival and gene expression. IL-4 is produced by mast cells; T cells; and bone marrow stromal cells. IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells; characterized by their cytokine-secretion profile that includes secretion of IL-4; IL-5; IL-6; IL-10; and IL-13; which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergic response.
• Abbreviation: Interleukin-4;IL-4
• Synonyms: Interleukin, B-cell growth factor, BSF, IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4, B-cell growth factor 1, B-cell IgG differentiation factor, B-cell stimulatory factor 1, Binetrakin, IGG1 induction factor, Interleukin-4, Lymphocyte stimulatory factor 1, Pitrakinra, IL2
• CAS Number: 9000-83-3
• UniProt: P05112
• Accession Number: P05112
• Host: HEK293 Cells
• Origin Species: Human
• Tag: None
• Sequence: His25-Ser153
• Applications: Cell culture
• Field of Research: Cancer;immunology
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.01-0.05 ng/ml.
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 18 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.