Recombinant Human Cyclophilin A Protein
CAT:
763-PKSH033420-02
Size:
10 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Human Cyclophilin A Protein
- Background: Peptidyl-prolyl cis-trans isomerase A is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family; which catalyzes the cis-trans isomerization of proline imidic peptide bonds. Cyclophilin A regulate many biological processes; including intracellular signaling; transcription; inflammation; and apoptosis. Cyclophilin is also incorporated into many viruses; including HIV1; where it has been speculated to be involved in functions such as viral assembly and infectivity. The immunosuppressive activity of cyclosporins has been correlated with their ability to form complexes with cyclophilins that inhibit calcineurin phosphatase activity and prevent incorporation of cyclophilin into viral particles. The cyclosporin/cyclophilin complex selectively binds and inactivates calcineurin; making it a useful inhibitor for studying calcineurin activity.
- Abbreviation: Cyclophilin A
- Synonyms: CYPA , Cyclophilin A, Cyclosporin A-binding protein, PPIA, PPIase A, Peptidyl-prolyl cis-trans isomerase A, Rotamase A, SP18
- CAS Number: 9000-83-3
- UniProt: P62937
- Accession Number: P62937
- Host: E. coli
- Origin Species: Human
- Tag: None
- Sequence: Met 1-Glu165
- Field of Research: Signal Transduction;immunology;
- Purity: > 95 % as determined by reducing SDS-PAGE.
- Bioactivity: Not validated for activity
- Reconstitution: Not Applicable
- Molecular Weight: 16 kDa
- Shipping Conditions: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
- Storage Conditions: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.