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Recombinant Human TGFB2 Protein

CAT: 0763-PKSH033139-01Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0763-PKSH033139-01Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD) .
Abbreviation
TGFB2
Synonyms
BSC-1 cell growth inhibitor; Cetermin; G-TSF; Glioblastoma-derived T-cell suppressor factor; Polyergin; TGF-beta-2; TGFB2; Transforming growth factor beta-2
UniProt
P61812
Accession Number
P61812
Expression System
HEK293 Cells
Tag
None
Sequence
Ala303-Ser414
Applications
Cell culture
Field of Research
Signal Transduction; Cell biology; Cancer; metabolism; Stem cells
Endotoxin
< 0.01 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Measured by its ability to inhibit the IL-4-dependent proliferation of TF-1 cells. The ED50 for this effect is 30-180pg/ml.
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
12.7 kDa
Observed Molecular Weight
12 kDa
Species
Human

UniProtKB · P61812

Transforming growth factor beta-2 proprotein

TGFB2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P61812
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TGFB2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B4DKC5, P08112, Q15579, Q15581, Q4VAV9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Disease

Aortic aneurysmDisease variant

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoprotein

Cellular component

Extracellular matrixSecreted

Molecular function

Growth factorMitogen

Domain

Signal

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