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Recombinant Human PDGF-BB Protein

CAT: 0763-PKSH032906-01Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0763-PKSH032906-01Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma.Binding of PDGFB to its receptor elicits a variety of cellular responses. In addition, PDGFB is released by platelets upon wounding and plays an important role in stimulating adjacent cells to grow and thereby heals the wound.
Abbreviation
PDGF-BB
Synonyms
Becaplermin; PDGF Subunit B; PDGF-2; PDGF2; PDGFB; Platelet-Derived Growth Factor B Chain; Platelet-Derived Growth Factor Beta Polypeptide; Platelet-Derived Growth Factor Subunit B; Proto-Oncogene c-Sis; SIS
UniProt
P01127
Accession Number
P01127
Expression System
E.coli
Tag
None
Sequence
Ser82-Thr190
Applications
Cell culture
Field of Research
Signal Transduction; Cardiovascular; Cancer; Developmental Biology; metabolism
Endotoxin
< 0.2 EU per μg of the protein as determined by the LAL method.
Purity
> 98 % as determined by reducing SDS-PAGE.
Bioactivity
50
Reconstitution
Please refer to the printed manual for detailed information.
Shipping Conditions
This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions
Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight
12.4 kDa
Observed Molecular Weight
14 kDa
Species
Human

UniProtKB · P01127

Platelet-derived growth factor subunit B

PDGFB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01127
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PDGFB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PDGF subunit B
EC number
—
Processing
Precursor
Secondary accessions
G3XAG8, P78431, Q15354, Q6FHE7, Q9UF23
Protein keywords

Technical term

3D-structureDirect protein sequencingPharmaceuticalProteomics identificationReference proteome

Coding sequence diversity

Alternative promoter usageChromosomal rearrangement

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoprotein

Molecular function

Developmental proteinGrowth factorMitogen

Disease

Disease variantProto-oncogene

Cellular component

Secreted

Domain

Signal
Product Datasheet
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