Recombinant Human Interleukin-22/IL-22 Protein (C-hIgG2 Fc)

• Background:

  Interleukin-22 (IL-22) is a member of a group of the IL-10 family; a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells. IL-22 and IL-10 receptor chains play a role in cellular targeting and signal transduction. It can initiate and regulate innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 along with IL-17 likely plays a role in the coordinated response of both adaptive and innate immune systems. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut similar to IL-10. Biological activity of IL-22 is initiated by binding to a cell-surface complex consisting of IL-22R1 and IL-10R2 receptor chains. IL-22 biological activity is further regulated by interactions with a soluble binding protein; IL-22BP. IL-22BP and an extracellular region of IL-22R1 share sequence similarity. In some cases; the pro-inflammatory versus tissue-protective functions of IL-22 are regulated by cytokine IL-17A.

• Abbreviation:

  IL-22

• Synonyms:

  UNQ; IL-D; Interleukin; Cytokine Zcyto; TIFIL; zcyto; IL22; IL-21; IL-22; IL-D110; IL-TIF; ILTIF; TIFIL-23; TIFa; zcyto18; UNQ3099/PRO10096; UNQ3099; Interleukin-22; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; PRO10096; IL-D110; ILTIF; IL-TIF; TIFa; TIFIL-23; zcyto18

• UniProt:

  Q9GZX6

• Accession Number:

  Q9GZX6

• Expression System:

  HEK293 Cells

• Tag:

  C-hIgG2 Fc

• Sequence:

  Ala34-Ile179

• Field of Research:

  Immunology

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  43.4 kDa

• Observed Molecular Weight:

  50-62 kDa

• Species:

  Human