Recombinant Human Interleukin-21/IL-21 Protein

• Background:

  IL-21 induces the production of IgG1 and IgG3 in B-cells. IL-21 may promote the transition between innate and adaptive immunity. IL-21 may have a role in proliferation and maturation of natural killer cells in synergy with IL15. IL-21 stimulates interferon gamma production in T-cells and natural killer cells by synergy with IL15 and IL18. Dysregulation of IL-21 has a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases.

• Abbreviation:

  Interleukin-21; IL-21

• Synonyms:

  CVID; Interleukin; IL21; CVID11; IL-21; Za11; Interleukin-21

• UniProt:

  Q9HBE4

• Accession Number:

  Q9HBE4

• Expression System:

  E.coli

• Tag:

  None

• Sequence:

  Gln30-Ser162

• Field of Research:

  Cancer; immunology

• Endotoxin:

  < 0.01 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  15.6 kDa

• Observed Molecular Weight:

  16 kDa

• Species:

  Human