Recombinant Human STUB1 Protein
CAT:
763-PKSH032367-02
Size:
10 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Human STUB1 Protein
- Background: E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. CHIP is highly expressed in skeletal muscle, heart, pancreas, brain and placenta. CHIP interacts with the molecular chaperones Hsc70-Hsp70 and Hsp90 through its TPR domain; lead to in client substrate ubiquitylation and degradation by the proteasome. CHIP targets misfolded chaperone substrates towards proteasomal degradation. CHIP mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. CHIP plays a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. It also may regulate the receptor stability and activity through proteasomal degradation.
- Abbreviation: STUB1
- Synonyms: Antigen NY-CO-7, CHIP, CLL-Associated Antigen KW-8, Carboxy Terminus of Hsp70-Interacting Protein, E3 Ubiquitin-Protein Ligase CHIP, STIP1 Homology and U Box-Containing Protein 1, STUB1
- CAS Number: 9000-83-3
- UniProt: Q9UNE7
- Accession Number: Q9UNE7
- Host: E. coli
- Origin Species: Human
- Tag: None
- Sequence: Met 1-Tyr303
- Field of Research: Signal Transduction;epigenetics and nuclear signal;
- Purity: > 95 % as determined by reducing SDS-PAGE.
- Bioactivity: Not validated for activity
- Reconstitution: Not Applicable
- Molecular Weight: 33 kDa
- Shipping Conditions: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
- Storage Conditions: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.