Recombinant Human ATF2 Protein (His & GST Tag)

Recombinant Human ATF2 Protein (His & GST Tag)

• Background: Activating transcription factor 2, also known as ATF2, is a member of the leucine zipper family of DNA-binding proteins that binds to the cAMP response element. Its activity is enhanced after phosphorylation by stress-activated protein kinases such as c-Jun N-terminal kinase and p38. ATF2 has been found to be a target of the JNK signal transduction pathway and mediate adenovirus E1A-inducible transcriptional activation. ATF2 is also been reported playing roles in TGF-β signaling pathway. It has been shown that the transcription factor ATF2 is bound by a hetero-oligomer of Smad3 and Smad4 upon TGF-β stimulation. Studies indicate that ATF-2 plays a central role in TGF-β signaling by acting as a common nuclear target of both Smad and TAK1 pathways.
• Synonyms: CRE-BP1, CREB-2, CREB2, HB16, TREB7
• CAS Number: 9000-83-3
• UniProt: P15336
• Accession Number: P15336-1
• Host: Baculovirus
• Origin Species: Human
• Tag: N-His-GST
• Sequence: Met 1-Ser 505
• Field of Research: Epigenetics and Nuclear Signaling,Immunology
• Purity: > 90 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 85 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.