Recombinant Human RELA/Transcription factor p65/NFkB p65 Protein (aa 1-306, GST Tag)

Recombinant Human RELA/Transcription factor p65/NFkB p65 Protein (aa 1-306, GST Tag)

• Background: RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a transcription factor expressed in growth plate chondrocytes where it facilitates chondrogenesis. The v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) gene encodes the major component of the NF-ĸB complex. NF-kappaB is a generic name for an evolutionarily conserved transcription-factor system that contributes to the mounting of an effective immune response but is also involved in the regulation of cell proliferation, development, and apoptosis. The implication of NF-kappaB in central biological processes and its extraordinary connectivity to other signaling pathways raise a need for highly controlled regulation of NF-kappaB activity at several levels. The mammalian Rel/NF-kappaB family of transcription factors, including RelA, c-Rel, RelB, NF-kappaB1 (p50 and its precursor p105), and NF-kappaB2 (p52 and its precursor p100), plays a central role in the immune system by regulating several processes ranging from the development and survival of lymphocytes and lymphoid organs to the control of immune responses and malignant transformation.
• Synonyms: NFKB3, p65
• CAS Number: 9000-83-3
• UniProt: Q04206
• Accession Number: Q04206-1
• Host: E. coli
• Origin Species: Human
• Tag: N-GST
• Sequence: Met 1-Tyr 306
• Field of Research: Cell Biology,Neuroscience,Microbiology,Signal Transduction,Epigenetics and Nuclear Signaling,Cancer,Cardiovascular,Metabolism
• Purity: > 85 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 58 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.