Recombinant Human IDH1 Protein (E.coli, His Tag)

Recombinant Human IDH1 Protein (E.coli, His Tag)

• Background: Isocitrate Dehydrogenase [NADP] Cytoplasmic (IDH1) belongs to the isocitrate and isopropylmalate dehydrogenases family. IDH1 exists as a homodimer; binding one magnesium or manganese ion per subunit. Mutations of IDH1 have been shown to cause metaphyseal chondromatosis with aciduria and are involved in the development of glioma IDH plays a role in the regeneration of NADPH for intraperoxisomal reductions; such as the conversion of 2; 4-dienoyl-CoAs to 3-enoyl-CoAs; as well as in peroxisomal reactions that consume 2-oxoglutarate; namely the α-hydroxylation of phytanic acid.
• Synonyms: Cytosolic NADP-Isocitrate Dehydrogenase, IDH, IDH1, IDP, Isocitrate Dehydrogenase [NADP] Cytoplasmic, NADP(+)-Specific ICDH, Oxalosuccinate Decarboxylase, PICD
• CAS Number: 9000-83-3
• UniProt: O75874
• Accession Number: O75874
• Host: E. coli
• Origin Species: Human
• Tag: C-His
• Sequence: Met 1-Leu 414
• Field of Research: Signal Transduction;Cancer;metabolism;
• Purity: > 95 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 43 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.