Recombinant Human IFNAR1/IFNAR Protein (Fc Tag)

Recombinant Human IFNAR1/IFNAR Protein (Fc Tag)

• Background: Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases; which in turn phosphorylate several proteins; including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due; at least in part; to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1; in which Tyr466 is changed to phenylalanine; can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.
• Synonyms: AVP, CRF2-1, Cytokine Receptor Class-II Member 1, Cytokine Receptor Family 2 Member 1, IFN-Alpha/Beta Receptor 1, IFN-R-1, IFN-alpha-REC, IFNAR, IFNAR1, Interferon Alpha/Beta Receptor 1, Type I Interferon Receptor 1
• CAS Number: 9000-83-3
• UniProt: P17181
• Accession Number: P17181-1
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-hFc
• Sequence: Met 1-Lys 436
• Field of Research: Immunology,Signal Transduction,Epigenetics and Nuclear Signaling
• Purity: > 88 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 100-120 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.