Recombinant Human IFNAR1/IFNAR Protein (Fc Tag)

• Background:

  Interferon-alpha/beta receptor alpha chain (IFNAR1) is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases; which in turn phosphorylate several proteins; including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. Tyk2 slows down IFNAR1 degradation and that this is due; at least in part; to inhibition of IFNAR1 endocytosis. Mutant versions of IFNAR1; in which Tyr466 is changed to phenylalanine; can act in a dominant negative manner to inhibit phosphorylation of STAT2. These observations are consistent with a model in which IFNAR1 mediates the interaction between JAK kinases and the STAT transcription factors.

• Synonyms:

  AVP; CRF2-1; Cytokine Receptor Class-II Member 1; Cytokine Receptor Family 2 Member 1; IFN-Alpha/Beta Receptor 1; IFN-R-1; IFN-alpha-REC; IFNAR; IFNAR1; Interferon Alpha/Beta Receptor 1; Type I Interferon Receptor 1

• UniProt:

  P17181

• Accession Number:

  P17181-1

• Expression System:

  HEK293 Cells

• Tag:

  C-hFc

• Sequence:

  Met 1-Lys 436

• Field of Research:

  Immunology, Signal Transduction, Epigenetics and Nuclear Signaling

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 88 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  74.0 kDa

• Observed Molecular Weight:

  100-120 kDa

• Species:

  Human