Recombinant Human FSTL1 Protein (His Tag)

Recombinant Human FSTL1 Protein (His Tag)

• Background: Follistatin-related protein 1 (FSTL1) is an extracellular glycoprotein whose functional significance in physiological and pathological processes is incompletely understood. Recently; we have shown that FSTL1 acts as a muscle-derived secreted factor that is up-regulated by Akt activation and ischemic stress and that FSTL1 exerts favorable actions on the heart and vasculature. Here; we sought to identify the receptor that mediates the cellular actions of FSTL1. It contains an FS module; a follistatin-like sequence containing 10 conserved cysteine residues. FSTL1 is thought to be an autoantigen associated with rheumatoid arthritis. DIP2A functions as a novel receptor that mediates the cardiovascular protective effects of FSTL1. Experiment results have provided in vivo and in vitro evidence to demonstrate that Fstl1 modulates lung development and alveolar maturation; in part; through BMP4 signaling.
• Synonyms: FRP, FSL1, MIR198
• CAS Number: 9000-83-3
• UniProt: Q12841
• Accession Number: NP_009016.1
• Host: HEK293 Cells
• Origin Species: Human
• Tag: C-His
• Sequence: Met 1-Ile 308
• Field of Research: Cell biology;Cardiovascular
• Purity: > 98 % as determined by reducing SDS-PAGE.
• Bioactivity: Not validated for activity
• Reconstitution: Please refer to the printed manual for detailed information.
• Molecular Weight: 47 kDa
• Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
• Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.