Recombinant Human Thioredoxin/TXN Protein
CAT:
763-PKSH030450-02
Size:
100 µg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Recombinant Human Thioredoxin/TXN Protein
- Background: Thioredoxin; also known as ATL-derived factor; Surface-associated sulphydryl protein; SASP and TXN; is a nucleus; cytoplasm and secreted protein which belongs to thethioredoxin family. Thioredoxins are proteins that act as antioxidants by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange. Thioredoxins are found in nearly all known organisms and are essential for life in mammals. Thioredoxin / TXN participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Thioredoxin / TXN plays a role in the reversible S-nitrosylation of cysteine residues in target proteins; and thereby contributes to the response to intracellular nitric oxide. Thioredoxin / TXN nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO); and thereby inhibits caspase-3 activity. Thioredoxin / TXN induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.
- Synonyms: ADF, ATL-Derived Factor, SASP, Surface-Associated Sulphydryl Protein, TRDX, TRX, TRX1, TXN, Thioredoxin, Trx
- CAS Number: 9000-83-3
- UniProt: P10599
- Accession Number: P10599
- Host: E. coli
- Origin Species: Human
- Tag: None
- Sequence: Met 1-Val 105
- Applications: Enzyme
- Field of Research: Signal Transduction;metabolism;
- Purity: > 97 % as determined by reducing SDS-PAGE.
- Bioactivity: Measured by its ability to catalyze the reduction of insulin. The reaction leads toprecipitation, which can be measured by absorbance at 650 nm. The specific activity is 5-10 A650/min/mg.
- Reconstitution: Please refer to the printed manual for detailed information.
- Molecular Weight: 14 kDa
- Shipping Conditions: This product is provided as lyophilized powder which is shipped with ice packs.
- Storage Conditions: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.