Recombinant Human MKK6 Protein (207 Ser/Asp, 211 Thr/Asp, His & GST Tag)

Recombinant Human MKK6 Protein (207 Ser/Asp, 211 Thr/Asp, His & GST Tag)

• Background: Dual specificity mitogen-activated protein kinase kinase 6, also known as MAP kinase kinase 6, MAPKK 6, MAPK / ERK kinase 6, SAPKK3, MAP2K6, and MKK6, is a protein that belongs to the protein kinase superfamily, STE Ser / Thr protein kinase family and MAP kinase kinase subfamily. MAP2K6 / MKK6 contains one protein kinase domain. Mitogen-activated protein kinases are members of a conserved cascade of kinases involved in many signal transduction pathways. They stimulate phosphorylation of transcription factors in response to extracellular signals such as growth factors, cytokines, ultraviolet light, and stress-inducing agents. MAP2K6 / MKK6 exists in a variety of alternatively spliced isoforms with distinct patterns of tissue expression. Isoform 2 of MAP2K6 / MKK6 is only expressed in skeletal muscle. Isoform 1 of MAP2K6 / MKK6 is expressed in skeletal muscle, heart, and to a lesser extent in liver or pancreas.
• Synonyms: MAP2K6 , MAPKK6, MEK6, MKK6, PRKMK6, SAPKK-3, SAPKK3
• CAS Number: 9000-83-3
• UniProt: P52564
• Accession Number: P52564-1
• Host: Baculovirus
• Origin Species: Human
• Tag: N-His-GST
• Sequence: Met 1-Asp 334; Ser 207/Asp; Thr 211/Asp
• Applications: Enzyme
• Field of Research: Cell Biology,Signal Transduction,Immunology,Cancer
• Purity: > 88 % as determined by reducing SDS-PAGE.
• Bioactivity: The specific activity was determined to be 1250 nmol/min/mg using inactive MAPK14 as substrate.
• Reconstitution: Not Applicable
• Molecular Weight: 60 kDa
• Shipping Conditions: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
• Storage Conditions: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.