Recombinant Human DCAMKL1 Protein (aa 1-705, His & GST Tag)

Recombinant Human DCAMKL1 Protein (aa 1-705, His & GST Tag)

• Background: DCAMKL1; also known as DCLK1; is a member of the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains; which bind microtubules and regulate microtubule polymerization; a C-terminal serine/threonine protein kinase domain; which shows substantial homology to Ca2+/calmodulin-dependent protein kinase; and a serine/proline-rich domain in between the doublecortin and the protein kinase domains; which mediates multiple protein-protein interactions. DCAMKL1 is involved in several different cellular processes; including neuronal migration; retrograde transport; neuronal apoptosis and neurogenesis. Its microtubule-polymerizing activity is independent of its protein kinase activity. DCAMKL1 may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. It may also participate in functions of the mature nervous system.
• Synonyms: CL1, CLICK1, DCAMKL1, DCDC3A, DCLK
• CAS Number: 9000-83-3
• UniProt: O15075
• Accession Number: O15075-1
• Host: Baculovirus
• Origin Species: Human
• Tag: N-His-GST
• Sequence: Met 1-Val 705
• Applications: Enzyme
• Field of Research: Neuroscience
• Purity: > 84 % as determined by reducing SDS-PAGE.
• Bioactivity: The specific activity was determined to be 6. 1 nmol/min/mg using synthetic Autocamtide-2 peptide (KKALRRQETVDAL-amide) as substrate.
• Reconstitution: Not Applicable
• Molecular Weight: 105 kDa
• Shipping Conditions: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
• Storage Conditions: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.