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Recombinant Human ERK3/MAPK12 Protein

CAT: 0763-PKSH030317Size: 50 µgDry Ice: NoHazardous: No
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CAT#:0763-PKSH030317Size:50 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ERK3; also known as MAPK12 and p38-gamma; belongs to theprotein kinase superfamily; CMGC Ser/Thr protein kinase family and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart.ERK3 is a serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly; p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK12 is required for the normal kinetochore localization of PLK1; prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.
Synonyms
ERK-6; ERK3; ERK6; MAPK12; P38-gamma; P38GAMMA; PRKM12; SAPK-3; SAPK3
UniProt
P53778
Accession Number
P53778
Expression System
Baculovirus-Insect Cells
Tag
None
Sequence
Met 1-Leu 367
Field of Research
Signal Transduction; Cell biology
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method.
Purity
> 95 % as determined by reducing SDS-PAGE.
Bioactivity
Not validated for activity
Reconstitution
Not Applicable
Shipping Conditions
This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions
Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight
42.1 kDa
Observed Molecular Weight
43 kDa
Formulation
Supplied as sterile solution of 20mM Tris, 500mM NaCl, 10% glycerol, pH 8.0
Species
Human

UniProtKB · P53778

Mitogen-activated protein kinase 12

MK12_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P53778
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAPK12
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MAP kinase 12, MAPK 12
EC number
2.7.11.24
Processing
—
Secondary accessions
Q14260, Q6IC53, Q99588, Q99672
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumMetal-bindingNucleotide-binding

Biological process

Cell cycleStress responseTranscriptionTranscription regulation

Cellular component

CytoplasmMitochondrionNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

PhosphoproteinUbl conjugation
Product Datasheet
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