Cleaved Caspase-9 P37 Polyclonal Antibody

CAT: 0763-E-AB-93363-01Size: 60 µLDry Ice: NoHazardous: No

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CAT#:0763-E-AB-93363-01Size:60 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein can undergo autoproteolytic processing and activation by the apoptosome, a protein complex of cytochrome c and the apoptotic peptidase activating factor 1; this step is thought to be one of the earliest in the caspase activation cascade. This protein is thought to play a central role in apoptosis and to be a tumor suppressor. Alternative splicing results in multiple transcript variants.

Abbreviation

Cleaved Caspase-9 P37

UniProt

P55211

Host

Rabbit

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant fusion protein of human Cleaved Caspase-9 P37

Target

CASP9; APAF-3; APAF3; ICE-LAP6; MCH6; PPP1R56; caspase-9; casp9; Caspase 9

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

WB; IHC; IF

Field of Research

Cancer; Cell Biology; Metabolism

Purification

Affinity purification

Concentration

1mg/mL

Dilution

WB 1:500-1:2000; IHC 1:50-1:200; IF 1:50-1:200

Buffer

PBS with 0.05% proclin300,50% glycerol, pH7.3.

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Calculated Molecular Weight

17kDa/30kDa/36kDa/46kDa

Observed Molecular Weight

35kDa/37kDa

Isotype

IgG

UniProtKB · P55211

Caspase-9

CASP9_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P55211
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: CASP9
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: CASP-9
EC number: 3.4.22.62
Processing: Precursor
Secondary accessions: B4E1A3, O95348, Q53Y70, Q5JRU9, Q5UGI1, Q92852, Q9BQ62, Q9UEQ3, Q9UIJ8

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

Molecular function

HydrolaseProteaseThiol protease

PTM

PhosphoproteinUbl conjugationZymogen

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