VEGF Polyclonal Antibody

CAT: 0763-E-AB-93319-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0763-E-AB-93319-01Size:60 μL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.
Abbreviation
VEGF
UniProt
P15692
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
A synthetic peptide of human VEGF
Target
VEGFA; MVCD1; VEGF; VPF; vascular endothelial growth factor A
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IF
Field of Research
Cancer; Cardiovascular; Metabolism; Developmental Biology; Signal Transduction
Purification
Affinity purification
Concentration
1mg/mL
Dilution
WB 1:500-1:2000; IF 1:50-1:200
Buffer
PBS with 0.01% thiomersal,50% glycerol, pH7.3.
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
15-27kDa/34-45kDa
Observed Molecular Weight
17KDa/45KDa
Isotype
IgG
Product Datasheet
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