Fenitrothion

• Description:

  Fenitrothion is a broad-spectrum and orally active insecticide/acaricide. Fenitrothion inhibits cholinesterase, AMPKα and IRS1/PI3K/AKT. Fenitrothion causes Apoptosis, reduces SOD activity. Fenitrothion shows insecticidal effect against Rhyzopertha dominica and Tribolium castaneum adults. Fenitrothion is widely used in cotton crops, vegetable crops, fruit crops and field crops, especially rice. Fenitrothion can be used for brain and spleen toxicology studies[1][2][3][4][5][6][7][8].

• UNSPSC:

  12352005

• Hazard Statement:

  H301, H312, H330, H410

• Target:

  Akt; AMPK; Apoptosis; Cholinesterase (ChE) ; Insecticide; Parasite; PI3K; SOD

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Apoptosis; Epigenetics; Immunology/Inflammation; Neuronal Signaling; Others; PI3K/Akt/mTOR

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/fenitrothion.html

• Purity:

  99.43

• Solubility:

  Ethanol : ≥ 200 mg/mL

• Smiles:

  S=P(OC)(OC)OC1=CC=C([N+]([O-])=O)C(C)=C1

• Molecular Formula:

  C9H12NO5PS

• Molecular Weight:

  277.23

• Precautions:

  H301, H312, H330, H410

• References & Citations:

  [1]Abdel-Ghany R, et al. Impact of Exposure to Fenitrothion on Vital Organs in Rats. J Toxicol. 2016;2016:5609734.|[2]Qing Hong, et al. A microcosm study on bioremediation of fenitrothion-contaminated soil using Burkholderia sp. FDS-1. International Biodeterioration & Biodegradation|[3]El-Shenawy NS. Effects of insecticides fenitrothion, endosulfan and abamectin on antioxidant parameters of isolated rat hepatocytes. Toxicol In Vitro. 2010 Jun;24 (4) :1148-57.|[4]Guo Y, et al. Fenitrothion induces glucose metabolism disorders in rat liver BRL cells by inhibiting AMPKα and IRS1/PI3K/AKT signaling pathway. Pestic Biochem Physiol. 2024 Sep;204:106098. |[5]Dal Bello G M, et al. Insecticidal efficacy of Beauveria bassiana, diatomaceous earth and fenitrothion against Rhyzopertha dominica and Tribolium castaneum on stored wheat. International journal of pest management, 2018, 64 (3) : 279-286.|[6]Adamski Z, et al. Effect of fenitrothion on Spodoptera exigua larval development and ultrastructure of follicle cells. Biologia, 2009, 64 (1) : 197-202. |[7]Li Q, et al. Effect of oral exposure to fenitrothion and 3-methyl-4-nitrophenol on splenic cell populations and histopathological alterations in spleen in Wistar rats. Hum Exp Toxicol. 2011 Jul;30 (7) :665-74.|[8]Alam RT, et al. Amelioration of fenitrothion induced oxidative DNA damage and inactivation of caspase-3 in the brain and spleen tissues of male rats by N-acetylcysteine. Life Sci. 2019 Aug 15;231:116534.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Mite

• CAS Number:

  [122-14-5]