Recombinant Transcription Factor 7 Like 2 Monoclonal Antibody

• Background:

  Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5' -CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small inTine.

• Abbreviation:

  Transcription Factor 7 Like 2

• UniProt:

  Q9NQB0

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  A synthetic peptide of human TCF-4

• Target:

  TCF7L2; HMG box transcription factor 4; HTCF-4; T-cell factor-4 variant X2; T-cell factor 4; Transcription factor 7-like 2; TCF-4

• Clonality:

  Monoclonal

• Clone:

  R09-1D1

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC-P

• Field of Research:

  Epigenetics and Nuclear Signaling; Cardiovascular; Metabolism

• Purification:

  Affinity Purified

• Concentration:

  300 μg/mL

• Dilution:

  WB 1:500-1:1000; IHC 1:50-1:100

• Buffer:

  50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  68kDa

• Observed Molecular Weight:

  68kDa

• Isotype:

  IgG