SIRT1 Polyclonal Antibody

CAT: 0763-E-AB-70368-01Size: 60 µLDry Ice: NoHazardous: No

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CAT#:0763-E-AB-70368-01Size:60 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

SIRT1, also named as SIR2L1, contains a deacetylase sirtuin-type domain and belongs to the sirtuin family. It regulates processes such as apoptosis and muscle differentiation by deacetylating key proteins. SIRT1 in particular initiates several signalling events relevant to cardioprotection, including: activation of endothelial nitric oxide synthase, insulin receptor signalling, and autophagy. In addition SIRT1 activation elicits resistance to oxidative stress via regulation of transcription factors and co-activators such as FOXO, Hif-2a, and NF-kB. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically at Lysine 382.

Abbreviation

SIRT1

UniProt

Q923E4

Host

Rabbit

Reactivity

Mouse

Immunogen

Recombinant protein corresponding to Mouse SIRT1

Target

75SirT1; hSIR2; hSIRT1; HST2; S. cerevisiae; homolog of; NAD dependent deacetylase sirtuin 1; NAD dependent protein deacetylase sirtuin 1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; SIR1; SIR2; SIR2 like 1; SIR2 like protein 1; SIR2; S.cerevisiae; homolog-like 1; SIR2-like protein 1; SIR2ALPHA; SIR2L1; Sirt1; SirtT1 75 kDa fragment; Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) ; Sirtuin 1; Sirtuin type 1

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Field of Research

Cancer; Cell Biology; Epigenetics and Nuclear Signaling; Metabolism; Microbiology; Tags and Cell Markers

Purification

Affinity purification

Concentration

1.2 mg/mL

Dilution

IHC 1:200-1:600

Buffer

PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG

UniProtKB · Q923E4

NAD-dependent protein deacetylase sirtuin-1

SIR1_MOUSE · Mus musculus

View on UniProt ↗

Primary accession: Q923E4
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: Sirt1
Protein existence: 1: Evidence at protein level
Organism: Mus musculus (Mouse)
Taxonomy ID: 10090
Alternative names: —
EC number: 2.3.1.286
Processing: —
Secondary accessions: Q9QXG8

Protein keywords

PTM

AcetylationMethylationPhosphoproteinS-nitrosylationUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisBiological rhythmsDifferentiationMyogenesisTranscriptionTranscription regulation

Cellular component

CytoplasmMitochondrionNucleus

Molecular function

Developmental proteinTransferase

Ligand

Metal-bindingNADZinc

Technical term

Reference proteome

Product Datasheet

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