S100A4 Polyclonal Antibody

• Background :

  S100A4 is a member of the S100 family of calcium-binding proteins. The S100 family members have been involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100A4 is known to localize to and function in the nucleus, cytoplasm of cells and the extracellular space. S100A4 has also been shown to be associated with tumor growth, motility, invasion, metastasis, angiogenesis, apoptosis and chemoresistance. It is a fibroblast-specific protein associated with mesenchymal cell morphology and motility, is expressed during epithelial-mesenchymal transformations (EMT) in vivo. It is an improved marker for lung fibroblasts that could be useful for investigating the pathogenesis of pulmonary fibrosis. Overexpression of S100A4 is correlated with a worse prognosis inpatients with various types of cancer.

• Abbreviation :

  S100A4

• UniProt :

  P26447, P07091, P05942

• Host :

  Rabbit

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Recombinant protein corresponding to Mouse S100A4

• Target :

  18A2;42A; calcium Placental protein; Calvasculin; CAPL; Fibroblast specific protein 1 (FSP1) ; Fibroblast specific protein 1; Fibroblast specific protein; FSP1; Leukemia multidrug resistance associated protein; Malignant transformation suppression 1 (MTS1) ; Malignant transformation suppression 1; Metastasin; MTS1; OTTHUMP00000015467; OTTHUMP00000015468; P9KA; PEL98; Placental calcium-binding protein; Protein Mts1; Protein S100 A4; Protein S100-A4; S100 calcium binding protein A4 (calcium protein; calvasculin; metastasin; murine placental homolog) ; S100 calcium binding protein A4; S100 calcium-binding protein A4; S100a4; S10A4

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  WB; IHC

• Field of Research :

  Cancer; Cardiovascular; Signal Transduction

• Purification :

  Affinity purification

• Concentration :

  0.75 mg/mL

• Dilution :

  WB 1:500-1:2000; IHC 1:300-1:800

• Buffer :

  PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  12kDa

• Observed Molecular Weight :

  12kDa

• Isotype :

  IgG