PDGFB Polyclonal Antibody

CAT: 0763-E-AB-70120-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0763-E-AB-70120-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 7, at sites where this gene and that for COL1A1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
Abbreviation
PDGFB
Host
Rabbit
Reactivity
Mouse; Rat
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse PDGFB
Target
Becaplermin; PDGF 2; PDGF B chain; PDGF subunit B; PDGF-2; PDGF2; Pdgfb; PDGFB; Platelet derived growth factor 2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Platelet-derived growth factor subunit B; Proto-oncogene c-Sis; SIS; SSV
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC; IF
Field of Research
Cancer; Cardiovascular; Metabolism; Developmental Biology; Signal Transduction
Purification
Affinity purification
Concentration
410 μg/mL
Dilution
WB 1:500-1:2000; IHC 1:200-1:400
Buffer
PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
27kDa
Observed Molecular Weight
27kDa
Isotype
IgG
Product Datasheet
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