GPX4 Polyclonal Antibody

CAT: 0763-E-AB-67390-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0763-E-AB-67390-01Size:60 μL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1Product image 2Product image 3Product image 4
1 / 4
Background
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS) . This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene.
Abbreviation
GPX4
UniProt
P36969
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant fusion protein of human GPX4
Target
GPX4; GPx-4; GSHPx-4; MCSP; PHGPx; SMDS; snGPx; snPHGPx
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IF
Field of Research
Cancer; Metabolism; Signal Transduction
Purification
Affinity purification
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000; IF 1:50-1:200
Buffer
PBS with 0.05% proclin300,50% glycerol, pH7.3.
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
19kDa/22kDa
Observed Molecular Weight
22KDa
Isotype
IgG

Related Products

CatalogName
AN200085PGPX4 Monoclonal Antibody
AN300726L-01Recombinant GPX4 Monoclonal Antibody
PDEH100537-01Recombinant Human GPX4 Protein (Sumo Tag)
E-BC-K883-M-01Glutathione Peroxidase 4 (GPX4) Activity Assay Kit
E-AB-66645-01GPX2 Polyclonal Antibody
E-AB-90540-01GPX3 Polyclonal Antibody
E-AB-93047-01GPX1 Polyclonal Antibody
E-AB-92236-01GPX8 Polyclonal Antibody
E-AB-70149-01GPX1 Polyclonal Antibody
AN000550P-01Glutathione Peroxidase 1/GPX1 Polyclonal Antibody (Capture/Detector)

Alternative Products

CatalogName
MBS2554925-01GPX4 Polyclonal Antibody
MBS9514758-01GPX4 Rabbit Polyclonal Antibody
HW551014-01Anti-GPX4 Polyclonal Antibody

Popular Products