RUNX2 Polyclonal Antibody

• Background:

  This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD) . Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

• Abbreviation:

  RUNX2

• UniProt:

  Q13950

• Host:

  Rabbit

• Reactivity:

  Human; Mouse

• Immunogen:

  Recombinant fusion protein of human RUNX2 (NP_001019801.3) .

• Target:

  RUNX2; AML3; CBF-alpha-1; CBFA1; CCD; CCD1; CLCD; OSF-2; OSF2; PEA2aA; PEBP2aA

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB

• Field of Research:

  Cancer; Epigenetics and Nuclear Signaling; Developmental Biology; Stem Cells

• Purification:

  Affinity purification

• Concentration:

  1mg/mL

• Dilution:

  WB 1:200-1:1000

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  54kDa/55kDa/56kDa

• Observed Molecular Weight:

  70kDa

• Isotype:

  IgG