RUNX2 Polyclonal Antibody

CAT: 0763-E-AB-62026-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0763-E-AB-62026-01Size:60 μL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD) . Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.
Abbreviation
RUNX2
UniProt
Q13950
Host
Rabbit
Reactivity
Human; Mouse
Immunogen
Recombinant fusion protein of human RUNX2 (NP_001019801.3) .
Target
RUNX2; AML3; CBF-alpha-1; CBFA1; CCD; CCD1; CLCD; OSF-2; OSF2; PEA2aA; PEBP2aA
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Epigenetics and Nuclear Signaling; Developmental Biology; Stem Cells
Purification
Affinity purification
Concentration
1mg/mL
Dilution
WB 1:200-1:1000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
54kDa/55kDa/56kDa
Observed Molecular Weight
70kDa
Isotype
IgG

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