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Caspase-8 Polyclonal Antibody

CAT: 0763-E-AB-62025-01Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-62025-01Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined.
Abbreviation
Caspase-8
UniProt
Q14790
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Recombinant fusion protein of human Caspase-8 (NP_001073593.1) .
Target
ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5; Caspase 8; CASP8; Caspase-8; caspase-8
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB; IHC; IF
Field of Research
Cancer; Cell Biology; Metabolism
Purification
Affinity purification
Concentration
1mg/mL
Dilution
WB 1:500-1:2000; IHC 1:50-1:200; IF 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
25-32kDa/45- 61kDa
Observed Molecular Weight
17kDa/44kDa/60kDa
Citation 01
https://www.sciencedirect.com/science/article/pii/S0753332221003772
Citation 02
https://www.mdpi.com/article/10.3390/plants12030529
Citation 03
https://www.mdpi.com/2072-6651/11/9/506
Citation 04
https://www.tandfonline.com/doi/abs/10.1080/13880209.2020.1765812
Isotype
IgG

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