CASP4 Polyclonal Antibody

• Background :

  This gene encodes a member of the cysteine proteases that plays important roles in apoptosis, cell migration and the inflammatory response. The encoded protein mediates production of pro-inflammatory cytokines by macrophages upon bacterial infection. Mice lacking the encoded protein are resistant to endotoxic shock induced by lipopolysaccharide. A 5-bp deletion encompassing a splice acceptor junction resulting in alternate splicing and a shorter non-functional isoform in certain mouse strains has been described. Although its official nomenclature is "caspase 4, apoptosis-related cysteine peptidase", this gene and its encoded protein have historically been called caspase 11. This gene is present in a cluster of three caspase genes on chromosome 9.

• Abbreviation :

  CASP4

• UniProt :

  P49662

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  Synthetic peptide of human CASP4

• Target :

  Apoptotic cysteine protease Mih1/TX; CASP-4; CASP4; CASP4; Caspase 4 apoptosis related cysteine peptidase; Caspase-4 subunit 2; Caspase4; ICE (rel) -II; ICE (rel) II; ICEREL II; ICH2; Mih1/TX; Protease ICH-2; Protease TX; TX

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Applications :

  IHC

• Field of Research :

  Cancer; Cell Biology; Metabolism

• Purification :

  Antigen affinity purification

• Concentration :

  0.7 mg/mL

• Dilution :

  IHC 1:30-1:150

• Buffer :

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Shipping Conditions :

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Isotype :

  IgG