LEPR Polyclonal Antibody

• Background:

  The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021) .

• Abbreviation:

  LEPR

• UniProt:

  P48357

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Synthetic peptide of human LEPR

• Target:

  CD 295; CD295; CD295 antigen; Db; Fa; HuB219; LEP R; LEP-R; LEPR; LEPR; LEPRD; Leptin receptor; Leptin receptor fatty; Leptin receptor gene related protein; Leptin receptor precursor; Leptin receptor precursor; OB R gene related protein; OB receptor; OB-R; OB-RGRP; obl; Obr

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Applications:

  WB; IHC

• Field of Research:

  Cancer; Cardiovascular; Metabolism; Signal Transduction

• Purification:

  Antigen affinity purification

• Concentration:

  0.84 mg/mL

• Dilution:

  WB 1:500-1:2000; IHC 1:40-1:200

• Buffer:

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Shipping Conditions:

  The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  133 kDa

• Observed Molecular Weight:

  Refer to figures

• Citation 01:

  https://onlinelibrary.wiley.com/doi/abs/10.1002/mrd.23342

• Isotype:

  IgG