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FLT1 Polyclonal Antibody

CAT: 0763-E-AB-53194-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-53194-01Size:20 µL
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Background
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig) -like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
Abbreviation
FLT1
UniProt
P17948
Host
Rabbit
Reactivity
Human
Immunogen
Synthetic peptide of human FLT1
Target
EC 2.7.10.1; FLT 1; FLT; Flt-1; FLT1; Fms like tyrosine kinase 1; Fms related tyrosine kinase 1; Fms related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) ; Fms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptor; Fms-like tyrosine kinase 1; FRT; Soluble VEGF receptor 1 14; Soluble VEGFR1 variant 2; Soluble VEGFR1 variant 21; Tyrosine protein kinase FRT; Tyrosine protein kinase receptor FLT; Tyrosine-protein kinase FRT; Tyrosine-protein kinase receptor FLT; Vascular endothelial growth factor receptor 1; Vascular endothelial growth factor vascular permeability factor receptor; Vascular permeability factor receptor 1; Vascular permeability factor receptor; VEGFR 1; VEGFR-1; VEGFR1; VGFR1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
IF
Field of Research
Cancer; Cardiovascular; Metabolism; Signal Transduction
Purification
Antigen affinity purification
Concentration
1.1 mg/mL
Dilution
IF 1:100-1:500
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Isotype
IgG

UniProtKB · P17948

Vascular endothelial growth factor receptor 1

VGFR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P17948
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FLT1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
VEGFR-1
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
A3E342, A3E344, A8KA71, B0LPF1, B2BF46, B2BF47, B2BF48, B3FR89, B5A923, F5H5L6, O60722, P16057, Q12954
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

AngiogenesisChemotaxisDifferentiation

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneCytoplasmEndosomeMembraneSecreted

Molecular function

Developmental proteinKinaseReceptorTransferaseTyrosine-protein kinase

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

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