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MAPK8 Polyclonal Antibody

CAT: 0763-E-AB-52157-02Size: 60 µLDry Ice: NoHazardous: No
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CAT#:0763-E-AB-52157-02Size:60 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MAPK8 (Mitogen-activated protein kinase 8) is also named as JNK1, PRKM8, SAPK1, SAPK1C and belongs to the MAP kinase subfamily. MAPK8 is activated by dual phosphorylation at a Thr-Pro-Tyr motif during response to UV light. MAPK8 functions to phosphorylate c-Jun at N-terminal serine regulatory sites of Ser-63 and Ser-73, mapping within the transactivation domain. Phosphorylation of these sites in response to UV results in transcriptional activation of c-Jun. It has 4 isoforms produced by alternative splicing with the molecular weight of 46 kDa and 48 kDa. This protein can be phosphorylated and this antibody recognizes the 46 kDa and 55 kDa bands in western blot.
Abbreviation
MAPK8
UniProt
P45983
Host
Rabbit
Reactivity
Human; Mouse; Rat
Immunogen
Fusion protein of human MAPK8
Target
AI849689; c Jun N terminal kinase 1; C-JUN kinase 1; c-Jun N-terminal kinase 1; EC 2.7.11.24; JNK 1; JNK; JNK-46; JNK1A2; JNK21B1/2; MAP kinase 8; MAPK 8; mapk8; Mitogen activated protein kinase 8; Mitogen-activated protein kinase 8; MK08; p54 gamma; Prkm8; Protein kinase JNK1; Protein kinase; mitogen-activated;8; SAPK 1; SAPK gamma; SAPK1; Stress-activated protein kinase 1; Stress-activated protein kinase JNK1
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB
Field of Research
Cancer; Immunology; Signal Transduction
Purification
Antigen affinity purification
Concentration
1.9 mg/mL
Dilution
WB 1:1000-1:5000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
48 kDa
Observed Molecular Weight
Refer to figures
Isotype
IgG

UniProtKB · P45983

Mitogen-activated protein kinase 8

MK08_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P45983
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MAPK8
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MAP kinase 8, MAPK 8
EC number
2.7.11.24
Processing
—
Secondary accessions
B5BTZ5, B7ZLV4, D3DX88, D3DX92, Q15709, Q15712, Q15713, Q308M2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Biological rhythms

Cellular component

CytoplasmNucleusSynapse

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

PhosphoproteinS-nitrosylation

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