KCNK10 Polyclonal Antibody

CAT: 0763-E-AB-52077-01Size: 20 µLDry Ice: NoHazardous: No

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CAT#:0763-E-AB-52077-01Size:20 µL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. KCNK10 (Potassium Two Pore Domain Channel Subfamily K Member 10) is a Protein Coding gene. Diseases associated with KCNK10 include Dentin Sensitivity. Among its related pathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK2.

Abbreviation

KCNK10

UniProt

P57789

Host

Rabbit

Reactivity

Human; Rat

Immunogen

Synthetic peptide of human KCNK10

Target

2P domain potassium channel TREK2; K2p10.1; KCNK10; KCNKA; Outward rectifying potassium channel protein TREK 2; Outward rectifying potassium channel protein TREK-2; Potassium channel subfamily K member 10; Potassium channel TREK 2; TREK 2; TREK 2 K; TREK 2 K (+) channel subunit; TREK-2 K (+) channel subunit; TREK2; TWIK related K+ channel 2

Clonality

Polyclonal

Conjugation

Unconjugated

Applications

IHC

Field of Research

Neuroscience

Purification

Antigen affinity purification

Concentration

0.96 mg/mL

Dilution

IHC 1:30-1:150

Buffer

PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Shipping Conditions

The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.

Storage Conditions

Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Isotype

IgG

UniProtKB · P57789

Potassium channel subfamily K member 10

KCNKA_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P57789
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: KCNK10
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: B2R8T4, B2RCT3, B5TJL4, Q6B014, Q8TDK7, Q8TDK8, Q9HB59

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoprotein

Molecular function

Ion channelPotassium channelVoltage-gated channel

Biological process

Ion transportPotassium transportTransport

Ligand

Potassium

Domain

TransmembraneTransmembrane helix

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Alternative Products

Catalog	Name
MBS8566952-01	KCNK10 Polyclonal Antibody
GTR17866469	KCNK10 Rabbit Polyclonal Antibody
NBP1-81571-25ul	Rabbit Polyclonal KCNK10 Antibody